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KMID : 0357520100330040321
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Journal of Radiological Science and Technology
2010 Volume.33 No. 4 p.321 ~ p.326
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Radiation-Induced IL(interleukin)-6 in Mice with Algin-Oligosaccharide Treatment
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Choi Sung-Kwan
Ji Youn-Sang
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Abstract
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To examine the radioprotective effect of algin-oligosaccharide(AOS), radiation-induced IL(interleukin)-6 in mice treated with 3 Gy whole body irradiation once were examined. In the measurement of irradiation-induced IL-6, in comparison with the irradiation control group, in both small intestine and liver tissues of the group treated with algin-oligosaccharide for 7 days prior to irradiation, was suppressed IL-6 synthesis(p < 0.001). It is considered that the protection against radiation hazard by antioxydative reaction of algin-oligosaccharide results in down control of IL-6 value in experimental groups treated with algin-oligosaccharide. In conclusion, through our study, the fact that algin-oligosaccharide has irradiation protection effects was elucidated, and simultaneously, the possibility of the use of a natural product without chemical toxicity as an irradiation protection agent was confirmed.
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KEYWORD
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Radiation-induced IL-6, Radiation-induced CYTOKINE, algin-oligosaccharide
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